I ran into a situation recently where users kept getting multiple passwords prompts when trying to access documents off SharePoint. It didn’t matter what kind of document the user was trying to open. Often they would be prompted as many as 2 or 3 times before the document would open and, it never made a difference if they checked to Remember Password or not. It was incredibly aggravating for my users and needed immediate attention.
Luckily the fix was quite simple